心肌游离脂肪酸的摄入和利用的失协调导致心肌中脂质积聚并进而引起脂毒性心肌病。脂质通过何种机制导致心肌功能的改变,以及如何来干预脂毒性心肌病成为当今心血管领域倍受关注的研究方向。现就脂毒性心肌病的发病机制及治疗进展做一综述。 Inconsistency in the uptake and utilization of free fatty acids in the myocardium leads to lipid accumulation in the myocardium and, in turn, to lipotoxic cardiomyopathy. The mechanisms by which lipids lead to changes in cardiac function and how to intervene in the treatment of lipotoxic cardiomyopathy become the focus of attention in the field of cardiovascular research. Now on the pathogenesis of lipotoxic cardiomyopathy and treatment progress to be reviewed.