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目的研究益气扶正复方提取物对小鼠免疫功能及荷瘤生存时间的影响。方法采用小鼠碳廓清法和鸡红细胞所致的血清溶血素抗体生成实验来观察益气扶正复方提取物对免疫的调节作用,通过检测S180腹水瘤小鼠生命延长率实验来测定药物对荷瘤小鼠的影响。结果益气扶正复方提取物低、中、高剂量组的脾脏系数,廓清指数K的值均大于醋酸泼尼松模型组(P<0.05);益气扶正复方提取物低、中、高剂量组及青春宝组的血清溶血素水平的值均大于空白组(P<0.01);益气扶正复方提取物低、中、高剂量组及氟尿嘧啶组的生命延长率均大于空白组(P<0.01)。结论益气扶正复方提取物具有提高机体免疫力和抗肿瘤作用。
Objective To study the effects of Yiqi Fuzheng Compound Extract on immune function and tumor-bearing survival time in mice. Methods Mouse carbon clearance method and chicken erythrocytes serum hemolysin antibody production experiments to observe the effects of Yiqi Fuzheng compound extract on immune regulation by measuring the life of S180 ascites tumor in mice to determine the rate of drug-induced tumor bearing Influence of mice. Results The spleen index and clearance index K of low, medium and high dose Yiqi Fuzheng Compound extract group were higher than that of prednisone acetate model group (P <0.05). The low, medium and high dose Yiqi Fuzheng Compound extract group (P <0.01). The life prolongation of low, medium and high dose Yiqi Fuzheng compound extract group and fluorouracil group were higher than that of blank group (P <0.01) . Conclusion Yiqi Fuzheng Compound Extract has the function of improving immunity and anti-tumor effect.