20世纪 6 0年代α2 肾上腺素能激动剂 (可乐定和胍法辛 )首先作为抗高血压药在临床广泛应用。 70年代 ,国外学者开始在精神科领域应用可乐定治疗抽动障碍。随后Ｈｕｎｔ等将其作为中枢兴奋剂的可替代药 ,治疗注意缺陷多动障碍(ａｔｔｅｎｔｉｏｎ ｄｅｆｉｃｉｔｈｙｐｅｒａｃ In the 1960s, α2 adrenergic agonists (clonidine and guanfacine) were first widely used clinically as antihypertensives. In the 1970s, foreign scholars began to apply clonidine in the psychiatric field to treat tic disorder. Hunt et al subsequently used it as an alternative to central stimulants to treat attention deficit hyperactivity disorder (attention deficityperactivity