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目的:探讨ST段抬高型急性冠脉综合征(STE-ACS)冠脉支架植入治疗前后T细胞亚群变化及其意义。方法:选取2014年1月至2016年3月在我院治疗的STE-ACS患者74例(病例组),同时选取健康志愿者80例作为对照组,检测两组外周血T淋巴细胞亚群水平。结果:病例组CD3~+、CD4~+和CD4~+/CD8~+分别为(0.622±0.070)%、(0.324±0.057)%和(0.987±0.122),明显低于对照组(P<0.05),而CD8~+为(0.330±0.031)%,明显高于对照组(P<0.05);病例组术后1周和2周CD3~+、CD4~+和CD4~+/CD8~+均较术前明显增加(P<0.05),而CD8~+较术前明显降低(P<0.05);根据TMP心肌灌注分级标准,冠脉支架植入1周后TMP 2~3级患者CD3~+、CD4~+和CD4~+/CD8~+分别为(0.731±0.050)%、(0.424±0.037)%和(1.763±0.109),明显高于TMP 0~1级组(P<0.05)。结论:STE-ACS患者外周血T细胞亚群异常,冠脉支架植入术后T淋巴细胞亚群明显改善。
Objective: To investigate the changes and their significance of T cell subsets before and after coronary stenting with ST-segment elevation acute coronary syndrome (STE-ACS). Methods: Totally 74 patients (case group) with STE-ACS treated in our hospital from January 2014 to March 2016 were enrolled in this study. Totally 80 healthy volunteers were selected as control group. The levels of T lymphocyte subsets . Results: The levels of CD3 ~ +, CD4 ~ + and CD4 ~ + / CD8 ~ + were significantly lower than those of the control group (P <0.05) (0.330 ± 0.031)%, which was significantly higher than that of the control group (P <0.05). CD3 ~ +, CD4 ~ + and CD4 ~ + / CD8 ~ (P <0.05). Compared with preoperative, the level of CD8 ~ + was significantly decreased (P <0.05). According to TMP myocardial perfusion grading standards, CD3 + (0.731 ± 0.050)%, (0.424 ± 0.037)% and (1.763 ± 0.109), respectively, which were significantly higher than those in TMP 0 ~ 1 group (P <0.05). Conclusion: T-cell subsets in peripheral blood of patients with STE-ACS are abnormal and T-lymphocyte subsets in coronary stents are significantly improved.