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目的探讨血清一氧化氮(nitric oxide,NO)、一氧化氮合酶(nitric oxide synthsae,NOS)的水平及其动态变化与急性一氧化碳中毒后迟发性脑病(delayed encephalopathy after acute carbon monoxide poisoning,DEACMP)患者病情变化的关系。方法应用比色法(colorimetric method)动态测定31例DEACMP患者血清NO及NOS水平,并与30例急性一氧化碳中毒(acute carbon monoxide poisoning,ACMP)后未发生迟发脑病患者和30例正常对照进行比较。结果 DEACMP患者急性期血清NO及NOS水平[(62.67±14.39)μmol/L,(27.68±6.14)U/mL]明显高于正常对照组[(50.18±9.95)μmol/L,(20.88±6.32)U/mL](均P<0.05),与ACMP组急性期[(62.00±16.46)μmol/L,(28.13±5.23)U/mL]比较无统计学差异(均P>0.05);DEACMP患者恢复期血清NO及NOS水平[(54.66±11.73)μmol/L,(21.74±5.88)U/mL]明显低于急性期(均P<0.05),与ACMP组随访期[(52.79±11.22)μmol/L,(20.64±5.92)U/mL]比较无统计学差异(均P>0.05)。结论 NO-NOS系统参与了DEACMP的发病机制,NO-NOS水平变化与病情变化基本一致。
Objective To investigate the relationship between serum levels of nitric oxide (NO), nitric oxide synthase (NOS) and their dynamic changes in patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP ) The patient’s condition changes. Methods The serum NO and NOS levels in 31 patients with DEACMP were measured dynamically by colorimetric method and compared with 30 patients without delayed encephalopathy after acute carbon monoxide poisoning (ACMP) . Results The levels of serum NO and NOS in acute stage of DEACMP patients were significantly higher than those in normal control group [(62.67 ± 14.39) μmol / L, (27.68 ± 6.14) U / mL] (50.18 ± 9.95 μmol / L, 20.88 ± 6.32, (P <0.05). There was no significant difference between ACMP group and control group (62.00 ± 16.46 μmol / L, 28.13 ± 5.23 U / mL, P <0.05) Serum levels of NO and NOS were significantly lower in the ACMP group than those in the ACMP group [(52.79 ± 11.22) μmol / L, (54.66 ± 11.73) μmol / L and 21.74 ± 5.88 U / mL, respectively] L, (20.64 ± 5.92) U / mL], there was no statistical difference (all P> 0.05). Conclusion The NO-NOS system participates in the pathogenesis of DEACMP. The change of NO-NOS level is consistent with the change of disease.