肾小球硬化与动脉粥样硬化极为相似。实验表明:高脂血症可使肾组织内某些生物代谢紊乱、血液动力及流变学改变,导致并加重蛋白尿和肾脏病理变化,脂蛋白异常尤其是受到修饰的脂蛋白的出现,载脂蛋白的异常等亦可造成肾内泡沫细胞形成,脂肪物质异常沉积、促进肾小球硬化。此外,肾内脂肪酸的变化也可影响前列腺素的代谢及细胞膜的结构,加重肾脏损伤。因此,脂质代谢异常可能在肾小球进行性病变中起到重要作用。 Glomerulosclerosis and atherosclerosis are very similar. Experiments show that: hyperlipidemia can make some of the biological metabolism of renal tissue disorders, hemodynamic and rheological changes, leading to and aggravate proteinuria and renal pathological changes, abnormal lipoprotein, especially modified lipoprotein, Abnormalities in lipoproteins, etc., can also cause formation of foam cells in the kidney, abnormal deposition of fatty substances, and promotion of glomerulosclerosis. In addition, changes in renal fatty acids can also affect prostaglandin metabolism and cell membrane structure, increase kidney damage. Therefore, abnormal lipid metabolism may play an important role in glomerular progressive lesions.