应用荧光偏振免疫法,测定6只家兔po卡马西平及连续多次po甲氧基红霉素后po卡马西平的血清卡马西平浓度,用3p87程序包按二室模型对数据进行处理并进行统计学分析.结果表明,合用甲氧基红霉素后,卡马西平峰浓度C_(max)升高38.3%,曲线下面积AUC增加32.6%,CI清除率减少28.5%(P<0.05).提示两者合用,应降低卡马西平的用量. Fluorescence polarization immunoassay was used to determine the concentration of serum carbamazepine in 6 rabbits po pomamazepine and po carbamazepine after repeated po po erythromycin, and the data were processed by 3p87 package according to 2-compartment model The results showed that the combination of methoxy erythromycin, carbamazepine peak concentration C max 38.3%, the area under the curve AUC increased 32.6%, CI clearance rate decreased 28.5% (P <0.05 ) Prompt combination of both, should reduce the amount of carbamazepine.