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目的：探讨早期连续性血液净化（CBP）对急性重症胰腺炎（SAP）临床疗效。方法：45例SAP患者随机分为治疗组（22例）和对照组（23例），两组均给予常规治疗，治疗组在常规治疗的基础上应用CBP早期干预。观察患者急性呼吸窘迫综合症持续时间、肠麻痹持续时间、肾功能恢复时间、低血钙持续时间、血淀粉酶恢复正常时间和住院日。结果：治疗组在急性呼吸窘迫综合症持续时间、肾功能恢复时间、低血钙持续时间、血淀粉酶恢复正常时间及住院日与对照组有统计学意义。治疗组有效率为90．91％，对照组治愈率为78．26％，两组有效率在差异有统计学意义（p＜0．05）。结论：本研究发现CBP治疗SAP对改善肾功能、缩短急性呼吸窘迫综合症持续时间、肠麻痹持续时间，改善预后、缩短住院时间、快速稳定内环境、减轻炎症反应有一定作用。“,”Objective :To investigate clinical efficacy early intervention therapy for severe acute pancreatitis (SAP) by continuous blood purification treatment (CBP) .Methods:45 cases of SAP patients were randomly divided into treatment group (22 cases) and control group (23 cases) ,both groups were given conventional therapy ,the treatment group on the basis of conventional treatment application of CBP early intervention .To observe duration of in patients with acute respiratory distress syndrome (ARDS) ,duration of intestinal paralysis ,renal function recovery time ,low blood calcium recovery time ,Recovery time of serum amylase and the hospital stay .Results:Compared with the control group ,the treatment group in the duration of acute respiratory distress syndrome ,kidney function recovery time and low blood calcium ,blood amylase returned to normal time and the hospital stay was statistically significant .Treatment group effective rate was 90 .91% ,control group cure rate was 78 .26% ,the difference was significant (p < 0 . 05) .Conclusion :This study found that CBP treatment of SAP to improve the kidney function ,shorten the duration of acute respiratory distress syn-drome ,duration of intestinal paralysis ,improve prognosis ,shorten hospitalization time ,fast ,stable internal environment ,reduce inflammation reactions have certain effect .