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系膜 IgA 肾病以系膜 IgA 沉积为特征,有关 IgA肾病伴恶性高血压很少报道。本文旨在探讨这种肾小球疾病恶性高血压的发生率及其临床表现和预后,作者对一组 IgA 肾病伴高血压患者作了回顾性研究。66例经肾活检证实为 IgA 肾病的成人患者,其中24例(36％)以高血压为首发症状,检测血压至少3次>140/95mmHg。将患者分成两组:A 组14例(21％)为良性高血压;B 组10例(15％)为恶性高血压。恶性高血压标准:多数情况下舒张压≥140mmHg,件Ⅲ～Ⅳ级高血压视网膜病和肾功能衰竭(肾衰)。肾活检标本作光镜及免疫荧光检查。5例患者测定了血清 IgA 浓度。
Mesangial IgA nephropathy is characterized by the presence of mesangial IgA deposits, few reports of IgA nephropathy with malignant hypertension. This article aims to investigate the incidence of malignant glomerular disease and its clinical manifestations and prognosis, the author of a group of IgA nephropathy with hypertension were retrospectively studied. Sixty-six adult patients with IgA nephropathy confirmed by renal biopsy, of whom 24 (36%) had hypertension as their first symptom and had a blood pressure> 140 / 95mmHg at least 3 times. Patients were divided into two groups: Group A 14 (21%) were benign hypertension; Group B 10 (15%) were malignant hypertension. Malignant Hypertension Standard: Diastolic blood pressure in most cases ≥ 140mmHg, grade Ⅲ ~ Ⅳ hypertensive retinopathy and renal failure (renal failure). Renal biopsy specimens for light microscopy and immunofluorescence. Serum IgA concentrations were measured in 5 patients.