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近年来,中草药水飞蓟的种子,已广泛应用于临床,其有效成分水飞蓟素(总黄酮),有较强的保肝作用,对急慢性肝炎或迁延性肝炎均有较好的疗效{全国中草药汇编,下册.12:,页,人民卫生出版社,1978;。目前常用剂型有将种子粉碎后作成蜜丸或散剂者,但剂量过大,疗程较长,服用不便。而自水飞蓟种子中提取其有效成分总黄酮压片,深受患者欢迎。国内生产单位是将水飞蓟种子粉碎后榨油,残饼用乙酸乙醋或95%乙醇提取,这个方法溶媒耗量大,工艺流程长
In recent years, the seeds of Chinese herbal medicine Milk thistle have been widely used in clinical practice. The active ingredient silymarin (the total flavonoids) has a strong liver protection effect and has a good effect on acute and chronic hepatitis or persistent hepatitis {National Herbal Medicine Compilation, vol.12, p., People’s Medical Publishing House, 1978. At present, the commonly used dosage forms are those that are made into honeyballs or powders after the seeds are crushed, but the dosage is too large, the treatment course is long, and it is inconvenient to take. The extraction of total flavonoid tablets of its active ingredients from the milk thistle seeds was welcomed by patients. The domestic production unit is to crush the milk thistle after the seeds are crushed, and the residual cake is extracted with ethyl acetate or 95% ethanol. This method consumes a lot of solvent and has a long process flow.