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目的探讨选择性定位的支气管肺泡灌洗液(BALF)配合气管镜刷片细胞学(BWC)检查对周围型肺癌的诊断价值。方法选择新疆医科大学附属肿瘤医院2012年1月-2014年1月收治的90例周围型肺癌患者,将所有患者平均分成3组,每组30例。支气管肺泡灌洗组选取BALF进行细胞学检查,支气管刷检组选取气管镜刷片进行检查(BWC),支气管肺泡灌洗液(BALF)配合气管镜刷片组则选取BALF配合气管镜刷片进行检查。对不同检查方法的癌细胞阳性率进行对比。结果支气管肺泡灌洗组癌细胞阳性率为43.33%,支气管刷检组癌细胞阳性率为36.67%,两组比较差异有统计学意义(P<0.05);支气管肺泡灌洗液(BALF)配合气管镜刷片组的癌细胞阳性率为70.00%,与支气管肺泡灌洗癌、支气管刷检组比较差异有统计学意义(P<0.05)。结论选择性的BALF配合刷片的细胞学检验癌细胞阳性率较单一的刷片检验阳性率显著提升,并且安全简单,为周围型肺癌早期诊断提供了一定的依据。
Objective To investigate the diagnostic value of selective bronchial alveolar lavage fluid (BALF) combined with bronchoscopy brush cytology (BWC) in the diagnosis of peripheral lung cancer. Methods Totally 90 patients with peripheral lung cancer admitted to Cancer Hospital Affiliated to Xinjiang Medical University from January 2012 to January 2014 were divided equally into 3 groups with 30 cases in each group. Bronchoalveolar lavage group selected BALF cytology, bronchial brush group selected tracheal brush examination (BWC), bronchoalveolar lavage fluid (BALF) with bronchoscopy brush group was selected BALF with bronchoscopy brush an examination. The positive rates of cancer cells in different examination methods were compared. Results The positive rate of cancer cells in bronchoalveolar lavage group was 43.33%, the positive rate of bronchial brush cells group was 36.67%, there was significant difference between the two groups (P <0.05); bronchoalveolar lavage fluid (BALF) The positive rate of cancer cells in mirror brush group was 70.00%, which was significantly different from that in bronchoalveolar lavage and bronchial brushing group (P <0.05). Conclusions The positive rate of cancer cells in selective BALF with brush cytology is significantly higher than that in single brush test, and it is safe and simple, which provides a basis for the early diagnosis of peripheral lung cancer.