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目的 观察复合辅酶对老年患者全身麻醉恢复期脑电双频指数(BIS)和苏醒质量的影响.方法 经腹胆囊切除术老年患者90例随机均分为三组:A组和B组切皮后30 min内分别静脉输注复合辅酶100 U和200 U;C组输注等容量生理盐水.记录三组患者诱导前、吸痰时、拔管时和拔管后1、5、10、15 min的HR和BIS值,记录拔管后1、5、10、15 min的Steward苏醒评分,比较两组手术时间、拔管时间、苏醒时间及丙泊酚、雷米芬太尼和顺苯阿曲库铵的用量.观察术中心律失常发生情况.结果 与 C 组相比,A 组和 B 组吸痰时、拔管时及拔管后1、5 min 的 BIS 值升高(P<0.05),拔管后1、5 min 的 Steward 苏醒评分升高(P<0.05),拔管时间和苏醒时间缩短(P<0.05).C组术中心律失常发生率高于A组和B组(30.0% vs.13.3% 和3.3%)(P<0.05),且A组高于B组(P<0.05).结论 手术切皮后静脉输注复合辅酶200 U可提高老年患者全身麻醉恢复期的BIS值及苏醒质量,并降低术中心律失常的发生率.“,”Objective To observe the effect of coenzyme complex on bispectral index(BIS)and recovery quality during recovery period of general anesthesia in elderly patients.Methods Ninety patients aged ≥ 65 years undergoing cholecystectomy under general anesthesia were equally randomized into three groups.The patients in groups of A and B were intravenously infused coenzyme complex 100 U and 200 U in 30 minutes after skin incision.The patients in group C were given equal volume of normal saline instead of coenzyme complex.HR and BIS were recorded before anesthesia induction,during sputum aspiration,during extubation and at 1,5,10 and 15 minutes after extubation. The operation time,extubation time,awakening time and Steward recovery scores at 1,5,10 and 15 minutes after extubation were recorded as well.The occurrence of arrhythmias in operation was observed.Results Compared with group C,BIS value during sputum aspiration,during extubation and at 1 and 5 minutes after extubation and Steward recovery scores at 1 and 5 minutes after extubation were increased(P<0.05),and extubation time and awakening time were shortened in groups of A and B(P<0.05).The incidence of arrhythmias in operation was higher in group C than those in groups of A and B(30.0% vs.13.3% and 3.3%)(P<0.05),which was higher in group A than that in group B (P<0.05).Conclusion Intravenous infusion of coenzyme complex 200 U in operation after skin incision is able to improve BIS value and recovery quality and reduce the occurrence of arrhythmia during recovery from general anesthesia in elderly patients.