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目的:研究HER-2/neu及β-catenin在粘液表皮样癌中的表达,探讨其在粘液表皮样癌中的作用及其临床意义。方法:应用免疫组织化学S-P法检测42例粘液表皮样癌及10例正常涎腺组织中HER-2/neu及β-catenin的表达。结果:粘液表皮样癌中HER-2/neu和β-catenin的阳性表达率分别为69.05%(29/42)和35.71%(15/42)与正常对照组存在显著性差异(P<0.05)。HER-2/neu和β-catenin的阳性率在不同分化程度的粘液表皮样癌中存有差异(P<0.05),β-catenin的表达与是否存在淋巴结转移有显著性关系(P<0.05)。结论:HER-2/neu及β-catenin的表达与粘液表皮样癌的病理分级有显著相关性,β-catenin与肿瘤转移明显相关,它们可作为判断肿瘤预后的辅助指标。
Objective: To investigate the expression of HER-2 / neu and β-catenin in mucoepidermoid carcinoma and to explore its role in mucoepidermoid carcinoma and its clinical significance. Methods: The expressions of HER-2 / neu and β-catenin in 42 cases of mucoepidermoid carcinoma and 10 cases of normal salivary gland were detected by immunohistochemical S-P method. Results: The positive rates of HER-2 / neu and β-catenin in mucoepidermoid carcinoma were 69.05% (29/42) and 35.71% (15/42) respectively, which were significantly different from those in normal control group (P <0.05) . The positive rates of HER-2 / neu and β-catenin in differentiated mucoepidermoid carcinoma were different (P <0.05). The expression of β-catenin was significantly correlated with lymph node metastasis (P <0.05) . CONCLUSION: The expression of HER-2 / neu and β-catenin is significantly correlated with the pathological grade of mucoepidermoid carcinoma. The expression of β-catenin is correlated with tumor metastasis, which may be used as an auxiliary index to judge the prognosis of the tumor.