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目的 观察清热消痤颗粒治疗炎症性痤疮对患者炎症细胞因子水平的影响.方法 选取我院门诊于2013年7月～2015年12月收治的青春期炎症性痤疮患者81例作为研究对象,分为观察组(43例)与对照组(38例).观察组应用清热消痤颗粒治疗,对照组口服丹参酮颗粒.比较两组治疗前后中医证候积分、治疗总有效率、治疗前后炎症细胞因子水平(IL-4、IFN-γ)、不良反应发生率.结果 两组治疗前的中医证候积分差异无统计学意义(P>0.05);治疗后两组中医证候积分均降低(P0.01). After treatment, the scores of two groups significantly decreased (P<0.01), integral of TCM symptoms in the observation group after treatment were significantly lower than the control group (P<0.05). Total effective rate of the observation group was 88.4％, which was significantly higher than the control group (68.4％) (P<0.05). After treatment, IL-4 in the two groups significantly decreased, IFN-γ significantly increased (P<0.05), IL-4 in the observation group after treatment was significantly lower than the control group, IFN -γ was significantly higher than the control group (P 0.05). Conclusion Qingre Xiaocuo granule in treatment of inflammation acne can dispelling-wind and clearing heat, wind-dispersing heat, removing blood stasis and toxin, hit the pathogenesis, reduce IL-4 and increase IFN-γ, with less adverse reactions.