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脑胶质瘤是中枢神经系统发病率最高的恶性肿瘤。在颅内各类型肿瘤中占第1位,其发病率为40％～60％。发病机制迄今尚未完全清楚,治疗仍是神经外科的一大难题。近年来,肿瘤分子生物学研究表明,癌基因的激活和肿瘤抑制基因的缺失是各种恶性肿瘤发生和发展的基础。目前已发现100多种癌基因和12种抑癌基因。1994年最新发现的抑癌基因P~(16)(MTSI、CDK_4I、CDKNI、P~(16)INK_4)在脑胶质瘤中纯合子缺失,基
Glioma is a malignant tumor with the highest incidence of central nervous system. In all types of intracranial tumors in the first place, the incidence rate of 40% to 60%. The pathogenesis has not yet been fully understood, the treatment of neurosurgery is still a major problem. In recent years, tumor molecular biology studies have shown that the activation of oncogenes and the loss of tumor suppressor genes are the basis for the occurrence and development of various malignancies. More than 100 oncogenes and 12 tumor suppressor genes have been discovered so far. The most recently discovered tumor suppressor gene P16 (MTSI, CDK4I, CDKNI, P16 (INK4)) was found to be deficient in gliomas