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目的研究定喘颗粒的止咳平喘作用,为其临床应用提供药理学依据。方法采用豚鼠离体气管条法、乙酰胆碱和磷酸组胺混合液致豚鼠哮喘、二氧化硫引咳小鼠和拘橼酸引咳豚鼠等模型,观察定喘颗粒的止咳平喘作用。结果定喘颗粒能明显抑制磷酸组胺、乙酰胆碱所致豚鼠离体气管条收缩,显著延长豚鼠哮喘潜伏期以及减少小鼠和豚鼠的咳嗽次数。结论定喘颗粒具有明显的止咳平喘作用。
Objective To study the anti-cough and anti-asthmatic effect of “Dingchuan Granule” and to provide a pharmacological basis for its clinical application. Methods Guinea pig bronchial asthma, sulfur dioxide induced cough mice and guinea pig citric acid cough guinea pigs were induced by guinea pig tracheal strip method. The cough and asthma of Dingchuan Granules were observed. Results Dingchuan Granule can significantly inhibit the contraction of tracheal strips induced by histamine and acetylcholine in guinea pigs, significantly prolong the latent period of asthma in guinea pigs and reduce the cough frequency in mice and guinea pigs. Conclusion Dingchuan Granule has obvious effect of relieving cough and asthma.