左旋门冬酰胺酶(L-asparaginase,L-Asp)是治疗急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)的经典药物,其作用原理是耗竭患者体内L天冬酰胺从而阻断肿瘤细胞的蛋白质合成,抑制肿瘤细胞代谢~([1-2])。但因其外源性蛋白质的特性,常引发机体过敏、骨髓抑制、凝血功能异常、生化指标异常、胃肠道不适等药物相关不良反应,影响药物的继续应用~([3-6])。培门冬酶(Pegaspargase,PEG-Asp)作为一种聚乙二醇化学偶联修饰后的新 L-Asparaginase (L-Asparaginase, L-Asp) is a classic drug for the treatment of acute lymphoblastic leukemia (ALL). The principle of L-asparaginase is to deplete L-asparagine from patients and block the protein synthesis of tumor cells , Inhibit tumor cell metabolism ~ ([1-2]). However, due to the characteristics of its exogenous proteins, it often leads to the body’s allergy, myelosuppression, coagulation disorders, biochemical abnormalities, gastrointestinal discomfort and other drug-related adverse reactions, affecting the continued use of drugs ~ ([3-6]). Pegaspargase (PEG-Asp) is a Newly Modified Polyethylene Glycol Coupling