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目的:观察正常非妊娠妇女、正常妊娠及妊娠高血压综合征(妊高征)患者血浆内皮素、神经肽Y及瘦素含量变化并探讨其在妊高征发病过程中的作用。方法:运用放射免疫法检测非孕妇女(正常组,23例)、正常妊娠妇女(妊娠组,60例)及妊高征患者(妊高征组,66例)血浆内皮素、神经肽Y及瘦素的含量。结果:妊高征组血浆内皮素的水平明显高于正常妊娠组,差异显著(P<0.01)。而妊高征组神经肽Y的水平较高于正常妊娠组明显高于正常组,差异显著(P<0.01)。瘦素的水平在妊高征组明显高于正常妊娠组和正常组,差异显著(P<0.05)。结论:妊高征患者血浆内皮素、神经肽Y及瘦素含量上升,提示神经体液因素在妊高征的发病过程中发挥了一定的作用且瘦素与妊娠高血压综合征有密切关系。是引起妊高征病理生理变化的重要因素。
Objective: To observe the changes of plasma endothelin, neuropeptide Y and leptin levels in normal non-pregnant women, normal pregnancy and pregnancy-induced hypertension syndrome (PIH) and to explore its role in the pathogenesis of PIH. Methods: The plasma levels of endothelin, neuropeptide Y and neuropeptide Y in non-pregnant women (normal group, 23 cases), normal pregnant women (pregnancy group, 60 cases) and PIH patients (66 cases PIH) Leptin content. Results: The plasma endothelin level in PIH group was significantly higher than that in normal pregnancy group (P <0.01). The level of neuropeptide Y in PIH group was significantly higher than that in normal pregnancy group (P <0.01). The leptin level in PIH group was significantly higher than that in normal pregnancy group and normal group (P <0.05). Conclusions: The plasma levels of endothelin, neuropeptide Y and leptin in patients with PIH rise, suggesting that neurohumoral factors play a role in the pathogenesis of PIH. Leptin and pregnancy-induced hypertension are closely related. Is caused by pregnancy-induced hypertension pathophysiological changes in an important factor.