我们依据肿瘤和慢性病“发病过程”主要特点 ,从因果探索“研究变量分类”、及不同类型变量“优化组合策略”研究入手 ,开发“状态”和“物元”概念的潜在优势 ,进行“设计水准分级” ,并依据各级水准设计中的变量关系 ,发展流行病学与生物统计学相结合 ,进行因果探索设计、模 Based on the main features of “pathogenesis” of cancer and chronic diseases, we started with the causal exploration of “research variable classification” and the research of different types of variables “optimal combination strategy” to develop the potential advantages of “state” and “Wuyuan” Level grading ", and in accordance with the level of variable design at all levels of the relationship between the development of epidemiology and biostatistics combined causal exploration design, the model