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本实验在诱发家兔冠状动脉粥样硬化的基础上,注射不同剂量的肾上腺素(Ad),导致动物猝死,从中观察心肌间微血栓在实验性冠心病猝死中的作用。结果表明,猝死动物微血栓的数量明显高于未猝死动物(P<0.01)。在注射Ad之后,随着存活时间的延长,微血栓的数量和成份都发生变化,一部分微血栓溶解,剩余的微血栓中混合性微血栓和纤维蛋白微血栓的比例增加。这说明体内儿茶酚胺大量分泌之后,血小板被激活,在心脏小血管内广泛形成微血栓,堵塞微循环,引起心肌缺血、心律紊乱而猝死。
In this study, rabbit induced coronary atherosclerosis based on the injection of different doses of adrenaline (Ad), causing sudden death in animals, from the observation of myocardial micro-thrombosis in experimental coronary heart disease in sudden death. The results showed that the number of sudden-death animals microthrombus was significantly higher than that of non-sudden death animals (P <0.01). After the injection of Ad, the number and composition of microthrombi were changed with the extension of survival time, and some microthrombi were dissolved. The proportion of mixed microthrombi and fibrin microthrombi in the remaining microthrombi increased. This shows that a large number of body secretion of catecholamines, platelets are activated in the small blood vessels within the formation of micro-thrombosis in a wide range of microcirculation, causing myocardial ischemia, cardiac arrest and sudden death.