论文部分内容阅读
目的 探讨窒息新生儿肾损害早期诊断的方法。方法 采用免疫浊度法和比色法分别测定尿微量白蛋白 (mALb)及N -乙酰 - β -D氨基葡萄糖苷酶 (NAG)。 结果 正常对照组尿mALb/Cr为 (1 5 9± 0 83)mg/mmol·Cr,NAG/Cr为 (0 96± 0 4 1)U/mmol·Cr。窒息新生儿尿mALb/Cr及NAG/Cr均较正常对照组增高 (P<0 0 1)。重度窒息组尿mALb的排泄量在不同日龄均较轻度窒息组增高 ;在生后 1、4、7天时重度窒息组比轻度窒息组尿NAG明显增高 ,差异显著 ,生后第 14天时 ,两组差异无显著性。部分尿mALb/Cr正常的窒息新生儿尿NAG/Cr增高。结论 联合检测尿mALb/Cr及NAG/Cr是诊断窒息新生儿肾脏早期损伤灵敏、可靠的实验室指标
Objective To investigate the early diagnosis of asphyxial neonatal renal damage. Methods Urine microalbumin (MALB) and N - acetyl - β - D - glucosaminidase (NAG) were determined by immunoturbidimetry and colorimetry respectively. Results The urinary mALb / Cr of the normal control group was (159 ± 0 83) mg / mmol · Cr and the NAG / Cr was (0 96 ± 0 4 1) U / mmol · Cr. Neonatal asphyxia urinary mALb / Cr and NAG / Cr were higher than the normal control group (P <0.01). Excretion of urinary mALb in severe asphyxia group was higher than that in mild asphyxia group at day 2. The urinary NAG in severe asphyxia group was significantly higher than that in mild asphyxia group at 1, 4 and 7 days after birth , No significant difference between the two groups. Partial urinary mALb / Cr normal asphyxia neonatal urine NAG / Cr increased. Conclusions The combined detection of urinary mALb / Cr and NAG / Cr is a sensitive and reliable laboratory indicator for early diagnosis of renal damage in neonatal asphyxia