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目的观察养阴润肺解毒方联合激素、抗生素治疗急性期放射性肺炎的临床疗效。方法将106例患者随机分为治疗组(56例)和对照组(50例),两组均采用激素、抗生素治疗,治疗组同时加服中药养阴润肺解毒方,观察两组近期症状及X线胸片疗效、肺炎评级变化、主要症状起效时间、血清细胞因子白介素6(IL-6)水平和生活质量评分。结果治疗后治疗组近期症状疗效、主要症状起效时间、肺炎评级改善程度、生活质量评分均优于对照组(P<0.05或P<0.01);两组X线胸片疗效比较,差异无统计学意义(P>0.05),但治疗组中完全缓解例数多于对照组;两组血清IL-6均较治疗前下降(P<0.05或P<0.01),治疗组下降水平较对照组更显著(P<0.01)。结论养阴润肺解毒方联合激素、抗生素治疗急性期放射性肺炎疗效确切,并能有效降低患者血清IL-6水平。
Objective To observe the clinical efficacy of Yangyin Runfei Jiedu Recipe combined with hormones and antibiotics in the treatment of acute radiation pneumonitis. Methods 106 patients were randomly divided into treatment group (56 cases) and control group (50 cases). Both groups were treated with hormones and antibiotics. At the same time, the treatment group was given traditional Chinese medicine Yangyin Runfei Jiedu Fang. The short-term symptoms, X-ray chest efficacy, changes in pneumonia rating, onset of major symptoms, serum levels of interleukin-6 (IL-6) and quality of life scores. Results After treatment, the curative effect, the onset time of main symptoms, the improvement of pneumonia rating and the quality of life score of the treatment group were better than those of the control group (P <0.05 or P <0.01). There was no significant difference in the curative effect between the two groups (P <0.05 or P <0.05). However, the number of complete remission cases in the treatment group was more than that of the control group. The levels of IL-6 in both groups were significantly lower than those before treatment (P <0.05 or P <0.01) Significant (P <0.01). Conclusion Yangyin Runfei Jiedu side combined with hormones, antibiotics in the treatment of acute radiation pneumonitis curative effect, and can effectively reduce the serum IL-6 levels.