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目的探讨细胞命运决定因子(DACH1)蛋白、脂肪酸合成酶(FASN)、固醇元件结合蛋白1(SREBP1)在子宫内膜癌中的表达及与临床病理参数的关系。方法应用免疫组织化学SP法检测DACH1、FASN、SREBP1在子宫内膜癌、不典型增生子宫内膜、复杂性子宫内膜、正常子宫内膜中的表达。结果 DACH1在子宫内膜癌中的表达显著低于非癌组,FASN及SREBP1在子宫内膜癌中的表达均显著高于非癌组。DACH1、FASN、SREBP1在子宫内膜癌中的表达率分别为40.0%、61.7%、65.0%,DACH1、FASN、SREBP1均与子宫内膜癌分化程度有关。DACH1与手术病理分期和病理类型有关,SREBP1与年龄有关。FASN、SREBP1与DACH1的表达呈负相关(r=-0.41,r=-0.40)。单因素分析结果显示,DACH1蛋白阳性组子宫内膜癌患者生存率高于DACH1蛋白阴性组(P<0.05);FASN及SREBP1蛋白阳性组子宫内膜癌患者生存率分别低于FASN蛋白及SREBP1蛋白阴性组(P<0.01,P<0.04)。结论 DACH1、FASN、SREBP1有可能成为子宫内膜癌判断预后的新指标。
Objective To investigate the expression of DACH1 protein, fatty acid synthase (FASN) and steroid binding protein 1 (SREBP1) in endometrial carcinoma and their relationship with clinicopathological parameters. Methods Immunohistochemical SP method was used to detect the expression of DACH1, FASN and SREBP1 in endometrial carcinoma, atypical hyperplasia endometrium, complex endometrium and normal endometrium. Results The expression of DACH1 in endometrial carcinoma was significantly lower than that in non-cancerous tissues. The expression of FASN and SREBP1 in endometrial carcinoma was significantly higher than that in non-cancerous ones. The expression rates of DACH1, FASN and SREBP1 in endometrial carcinoma were 40.0%, 61.7% and 65.0%, respectively. DACH1, FASN and SREBP1 were correlated with the degree of differentiation of endometrial carcinoma. DACH1 and surgical pathology staging and pathological types, SREBP1 and age. FASN, SREBP1 and DACH1 expression was negatively correlated (r = -0.41, r = -0.40). The results of univariate analysis showed that the survival rate of patients with DACH1 positive endometrial cancer was significantly higher than that of DACH1 negative patients (P <0.05). The survival rates of patients with FASN and SREBP1 positive endometrial cancer were lower than those of FASN and SREBP1 Negative group (P <0.01, P <0.04). Conclusion DACH1, FASN and SREBP1 may be the new prognostic indicators of endometrial cancer.