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目的:研究盐酸戊乙奎醚用于心脏手术术前药的有效性和安全性。方法:以40例先天性心脏病手术患儿为研究对象,随机分成戊乙奎醚组(A组)和东莨菪碱(B组)。结果:给药后30 min与给药前比较:A组HR和体温无明显变化,B组HR和体温明显升高(P<0.05,P<0.01)两组给药前后BP差异无统计学意义。两组给药后30 min面红、头晕、呕吐等不良反应发生率差异无统计学意义,但A组拔管后恶心、呕吐发生率明显降低(P<0.05)。结论:盐酸戊乙奎醚能够更好地保持心脏病患者血流动力学的稳定。
Objective: To study the efficacy and safety of penehyclidine hydrochloride in preoperative medicine for cardiac surgery. Methods: Forty patients with congenital heart disease undergoing cardiac surgery were randomly divided into penehyclidine group (A group) and scopolamine group (B group). Results: Compared with pre-administration, HR and body temperature in group A were not significantly changed at 30 min after administration, while HR and body temperature in group B were significantly increased (P <0.05, P <0.01). There was no significant difference in BP before and after administration . There was no significant difference in the incidence of redness, dizziness and vomiting 30 min after the administration in both groups, but the incidence of nausea and vomiting was significantly lower in group A after extubation (P <0.05). Conclusion: Penehyclidine hydrochloride can better maintain the hemodynamic stability in patients with heart disease.