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食管柱状上皮/肠上皮化生黏膜是食管腺癌的重要发生基地,现已阐明GERD和反流性食管炎于其发生与进展上起巨大作用。由胃开始连续覆盖柱状上皮的食管称做柱状上皮食管,此在日本与Barrett食管同义。在欧美从腺癌发生风险角度而言,却多是只将肠上皮化生者认作为Barett食管,因而有定义差异。目前食管癌基本上是鳞状上皮癌,在反流性食管炎多属轻症的日本,不论有无GERD,必须将整个食管胃结合部附近的腺癌纳入诊疗与研究的视野。
Esophageal columnar epithelium / intestinal metaplasia mucosa is an important base of esophageal adenocarcinoma has been clarified GERD and reflux esophagitis in its occurrence and progress play a significant role. The esophagus, which continuously covers the columnar epithelium from the stomach, is called the columnar epithelial esophagus, which is synonymous with the Barrett’s esophagus in Japan. In Europe and the United States from the perspective of the risk of adenocarcinoma, but more than just intestinal metaplasia who recognize as Barett esophagus, and therefore have defined the difference. At present, esophageal cancer is basically squamous cell carcinoma. In the case of reflux esophagitis, which is mostly mild in Japan, whether it has GERD or not, the entire esophagogastric junction must be included in the field of diagnosis and research.