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5. The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies

The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies

来源 :癌症：英文版 | 被引量 : 0次 | 上传用户：PEARTREE123

【摘 要】

：

Cullin 4A(CUL4A)is an E3 ubiquitin ligase that directly affects DNA repair and cell cycle progression by targeting substrates including damage-specific DNA-bind

【作 者】

：

Jeffrey Hanna Peng-Bo Zhou 

【机 构】

：

DepartmentofPathologyandLaboratoryMedicine,DepartmentofPathologyandLaboratoryMedicine

【出 处】

：

癌症：英文版

【发表日期】

：

2013年9期

【关键词】

：

泛素连接酶 恶性肿瘤 皮肤癌 治疗 DNA修复 DNA结合蛋白 靶点 细胞水平 Ubiquitination  cullins  DNA damage  cel 

【基金项目】

：

supported by grants from National Institutes of Health Grant(No.CA098210),,the Natural Science Foundation of China(No.30901754),,the Tianjin City Thousand Person Plan grants,,supported in part by a Ru

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论文部分内容阅读

Cullin 4A(CUL4A)is an E3 ubiquitin ligase that directly affects DNA repair and cell cycle progression by targeting substrates including damage-specific DNA-binding protein 2(DDB2),xeroderma pigmentosum complementation group C(XPC),chromatin licensing and

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