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目的:对比研究盐酸戊乙奎醚治疗急性重度有机磷中毒的效果及安全性。方法:将急性重度有机磷中毒患者56例随机分为实验组(n=28)和对照组(n=28),实验组盐酸戊乙奎醚伍用氯磷定、对照组阿托品伍用氯磷定治疗,对两组进行比较分析。结果:在同等条件下盐酸戊乙奎醚的用药总量及用药次数均明显少于阿托品,治愈率高,不良反应少。结论:盐酸戊乙奎醚是一种新型、安全、高效、低毒的治疗急性有机磷中毒较理想的长效抗胆碱药物。
Objective: To compare the efficacy and safety of penehyclidine hydrochloride in the treatment of acute severe organophosphate poisoning. Methods: Fifty-six patients with acute severe organophosphate poisoning were randomly divided into experimental group (n = 28) and control group (n = 28). Penehyclidine hydrochloride group was treated with chlorpheniramine in the experimental group, Given treatment, comparative analysis of the two groups. Results: Under the same conditions, the total amount of penehyclidine hydrochloride used and the number of administration were significantly less than atropine, the cure rate is high, with fewer adverse reactions. Conclusion: Penehyclidine hydrochloride is a new, safe, efficient and low toxicity long-acting anticholinergic drug for acute organophosphate poisoning.