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目的:探讨联合使用阿德福韦酯和拉夫米定治疗慢性乙肝(乙型肝炎)的临床效果。方法:对2012年1月~2014年1月期间我院收治的60例慢性乙肝患者的临床资料进行回顾性研究。我们将这60例患者随机分为观察组、对照1组和对照2组,每组各有20例患者。我院使用拉米夫定对对照1组患者进行治疗,使用阿德福韦酯对对照2组进行治疗,联合使用拉米夫定和阿德福韦酯对观察组患者进行治疗。治疗结束后,比较三组患者治疗的效果、治疗前后其ALT(谷丙转氨酶)的水平、AST(谷草转氨酶)的水平、Scr(肌酐)的水平和HBV-DNA(乙肝病毒的脱氧核糖核酸)、Hbe Ag(乙型肝炎E抗原)的转阴率。结果:观察组患者治疗的总有效率明显高于对照1组和对照2组患者,组间比较差异具有显著性(P<0.05)。治疗结束后,观察组患者ALT的水平、AST的水平和Scr的水平均明显低于对照1组和对照2组患者,组间比较差异具有显著性(P<0.05)。治疗结束后,观察组患者HBV-DNA的转阴率和Hbe Ag的转阴率均明显高于对照1组和对照2组患者,组间比较差异具有显著性(P<0.05)。结论 :联合使用阿德福韦酯和拉夫米定治疗慢性乙肝的效果确切,可有效地促进其HBV-DNA、Hbe Ag的转阴和肝功能的恢复。此联合用药方法可作为临床上治疗慢性乙肝的优选方法。
Objective: To investigate the clinical effect of combined use of adefovir dipivoxil and lamivudine in the treatment of chronic hepatitis B (Hepatitis B). Methods: The clinical data of 60 patients with chronic hepatitis B treated in our hospital from January 2012 to January 2014 were retrospectively studied. We divided these 60 patients into observation group, control group 1 and control group 2, each with 20 patients in each group. In our hospital, lamivudine was used to treat patients in control group 1, adefovir dipivoxil in control group 2 and lamivudine and adefovir dipivoxil in the observation group. After the treatment, the effect of the three groups of patients was compared, the level of ALT (alanine aminotransferase), the level of AST (aspartate aminotransferase), the level of Scr (creatinine) and the level of HBV DNA (hepatitis B virus deoxyribonucleic acid) , Hbe Ag (Hepatitis B E antigen) negative conversion rate. Results: The total effective rate of observation group was significantly higher than that of control group 1 and control group 2, with significant difference between the two groups (P <0.05). After treatment, ALT level, AST level and Scr level in observation group were significantly lower than those in control group 1 and control group 2 (P <0.05). After the treatment, the negative rate of HBV-DNA and the negative rate of Hbe Ag in observation group were significantly higher than those in control group 1 and control group 2 (P <0.05). Conclusion: The combination of adefovir dipivoxil and lamivudine in the treatment of chronic hepatitis B is effective and can effectively promote the recovery of HBV-DNA, Hbe Ag and liver function. This combination therapy can be used as a clinical treatment of chronic hepatitis B is the preferred method.