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本文研究硝苯吡啶对慢性肺源性心脏病血液动力学的影响,对21例临床急性发作期慢性肺源性心脏病患者作心肺阻抗微分图检查,其中治疗组9例,对照组13例。结果表明口服常规剂量硝苯吡啶1周与2周末时,患者的肺动脉压、肺血管阻力、平均动脉压及外周血管阻力与治疗前相比,明显下降,氧输送量及心指数于治疗2周末时也明显增加。本文认为常规剂量硝苯吡啶治疗缺氧性肺动脉高压有效,能降低肺动脉压、肺血管阻力,改善心脏功能,一般不会导致体循环低血压及加重低氧血症。
This study was to investigate the effect of nifedipine on hemodynamics in patients with chronic cor pulmonale. The differential diagnosis of cardiopulmonary respiration was performed in 21 patients with chronic cor pulmonale during acute exacerbation, including 9 in the treatment group and 13 in the control group. The results showed that oral administration of conventional doses of nifedipine 1 week and 2 weekend, the patient’s pulmonary artery pressure, pulmonary vascular resistance, mean arterial pressure and peripheral vascular resistance compared with before treatment decreased significantly, oxygen delivery and cardiac index in the treatment of 2-weekend When also significantly increased. This paper argues that conventional doses of nifedipine treatment of hypoxic pulmonary hypertension effective, can reduce pulmonary arterial pressure, pulmonary vascular resistance, improve cardiac function, generally does not lead to systemic hypotension and aggravate hypoxemia.