皮肤粘膜黑色素斑—胃肠道多发性息肉综合征(以下简称黑斑息肉综合征)是一种罕见疾病。Hutcnhinson(1896)首次报告一对双生姐妹唇、口周围及口腔粘膜等处均有色素斑点,但未注意到胃肠道息肉。Peutz(1921)报导一家三代人中有七人发病,除色素斑点外并伴有胃肠多发性息肉。Jeghers等(1949)收集了10例典型病例,加以系统描述,故称Peutz Mucocutaneous Membrane - Multiple gastrointestinal polyps syndrome (hereinafter referred to as melasma polyps syndrome) is a rare disease. Hutcnhinson (1896) reported for the first time that a pair of twin sisters had pigment spots around the lips, mouth, and oral mucosa, but did not notice gastrointestinal polyps. Peutz (1921) reported that seven out of a third generation had onset, with pigment spots and gastrointestinal polyps. Jeghers et al. (1949) collected 10 typical cases and described them systematically. It was called Peutz.