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目的:探讨新疆哈萨克族食管鳞癌患者中人乳头瘤状病毒(HPV)16型的检出率。方法:采用半巢式PCR技术检测150例新疆哈萨克族食管癌石蜡包埋组织、40例正常食管粘膜活检组织中HPV16型,分析其与新疆哈萨克族食管癌发生的相关性。结果:在新疆哈萨克族食管癌组织中,HPV16型检出率为38.7%(58/150),与对照组10%(4/40)相比,差异有统计学意义(χ2=11.805,P<0.05)。结论:HPV16型感染与新疆哈萨克族食管癌的发生存在一定的相关性。
Objective: To explore the detection rate of human papillomavirus (HPV) type 16 in Kazakh Kazakh esophageal squamous cell carcinoma. Methods: Semi-nested PCR was used to detect HPV16 in 150 cases of Xinjiang Kazakh esophageal paraffin-embedded tissues and 40 cases of normal esophageal mucosa biopsies. The correlation between HPV16 and Xinjiang Kazakh Kazakh esophageal carcinomas was analyzed. Results: The positive rate of HPV16 was 38.7% (58/150) in Kazakh Kazakh esophageal cancer tissues, which was significantly different from that of the control group (10%, 4/40) (χ2 = 11.805, P < 0.05). Conclusion: There is a certain correlation between HPV16 infection and the occurrence of esophageal cancer in Kazak of Xinjiang.