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二缩三乙二醇双环氧丙基醚(Etoglucid),化学名:1,2,15,16-二环氧基-4,7,10,13-四氧代十六烷,为抗肿瘤化疗剂。据报道本品对膀胱乳头状肿瘤疗效较好。国内已试用于临床,为了提供药源扩大临床观察,我们乃试制此药,并对其合成工艺路线作了探讨和改进。按英国专利报道有下列二种合成方法。方法一用二缩三乙二醇为原料,与环氧氯丙烷一步反应制得成品。此法反应步骤虽少,原料价格也低廉,但产品含量低,难于纯化。
Etoglucid, chemical name: 1,2,15,16-diepoxy-4,7,10,13-tetraoxohexadecane, anti-tumor Chemotherapy agent. It is reported that this product is better curative effect on papillary tumors of the bladder. China has been tried in clinical trials, in order to provide medicine to expand the clinical observation, we are trying out the drug, and its synthetic route were discussed and improved. According to the British patent reports the following two synthetic methods. Method one with triethylene glycol as raw material, and epichlorohydrin one step reaction finished. Although this method reaction steps are small, raw material prices are low, but the product content is low, difficult to purify.