设计并制成了一种强力霉素胶囊剂(C-4),经9名志愿者口服后,用荧光分光光度法测定了血药浓度,与等剂量强力霉素片剂对比,C-4的AUC、Cm较片剂分别高出38.6％和35.2％,t检验结果差别显著,是一种高生物利用度制剂。用PEP Ⅱ-2药物动力学程序,按两室模型计算出两种剂型的Ka、Tm、t_(1/2)等参数。 A doxycycline capsule (C-4) was designed and prepared. After oral administration to 9 volunteers, the plasma concentration was determined by fluorescence spectrophotometry. Compared with the equivalent dose of doxycycline tablets, C-4 The AUC and Cm were 38.6% and 35.2% higher than the tablets, respectively. The t-test results showed significant differences, which was a high bioavailability formulation. Using PEP Ⅱ-2 pharmacokinetic program, the Ka, Tm and t_ (1/2) parameters of the two dosage forms were calculated according to a two-compartment model.