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Macnab 等通过体外实验证明石棉能引起溶血和巨噬细胞释放乳酸脱氢酶;并指出温石棉能与细胞膜的糖蛋白发生相互作用。本文研究红细胞膜或脂质体处理温石棉纤维之后,使其溶血速率减慢;温石棉与脂质相互作用能显著地改变细胞膜或肺表面活性物质的完整性和稳定性,改变它们的物理特性。作者实验采用 UICC 温石棉和青石棉样品。温石棉纤维长<5μm,青石棉纤维长<4μm。蒸馏水溶解红细胞获得红细胞膜。二棕榈酰卵磷脂或以7:2:1克分子比率的二棕榈酰卵磷
Macnab and other in vitro experiments show that asbestos can cause hemolysis and release of lactate dehydrogenase from macrophages; and pointed out that chrysotile and cell membrane glycoprotein interaction. In this paper, the erythrocyte membrane or liposome treatment of chrysotile fibers, so that the rate of hemolysis slow; chrysotile and lipid interactions can significantly change the cell membrane or pulmonary surfactant integrity and stability, to change their physical properties . The authors used UICC asbestos and crocidolite samples. Chrysotile fiber length <5μm, crocidolite fiber length <4μm. Erythrocyte membrane was obtained by dissolving erythrocytes in distilled water. Dipalmitoyl lecithin or dipalmitoyl lecithin in a molar ratio of 7: 2: 1