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Dear Editor,Identification of oogonia stem cells would have great potentials in infertility treatment and fertility preservation.Here we tested whether Fragilis/Ifitm3 can identify oogonia stem cells in fetal mouse ovaries and their molecular features,if it can,and whether the oogonia stem cells marked by Fragilis can be found in the postnatal ovaries.It is well established that the primordial germ cells (PGCs) in embryonic gonads undergo multiple cell divisions during migration to the genital ridge to produce oogonia that can differentiate into meiotic cells (Saitou and Miyauchi,2016),and thus are definitive oogonia stem cells.