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目的 探讨胆囊癌与妊娠的关系。方法 采用全人群病例对照研究,研究对象为1997 年6 月1 日~2001 年5 月31 日期间确诊、年龄在35~74岁的上海市区女性胆囊癌269例以及按年龄(5岁一组)频数配对的538名人群对照,采用非条件lo gistic回归模型分析妊娠与胆囊癌的关系。结果 胆囊癌合并胆石症者中,与妊娠次数≤2 次者比较,妊娠次数(3 次,4 次,5次及≥6次)的各组调整OR分别为1.33(95%CI: 0.59 2.99),1.34(95%CI: 0.58 3.11),1.39(95%CI: 0.57 3.43)和2.67(95%CI: 1.12 6.41),趋势检验P=0.03。结论 多次妊娠可能通过胆石症影响胆囊癌的发生,生育因素导致的女性体内雌、孕激素水平的升高可能在胆囊癌病因学中起一定的作用。
Objective To investigate the relationship between gallbladder cancer and pregnancy. Methods The case-control study of the whole population was conducted in 269 cases of female patients with gallbladder carcinoma in Shanghai and 35 to 74 years of age who were diagnosed between June 1, 1997 and May 31, 2001, ) Frequency of 538 pairs of matched controls, non-conditional lo gistic regression model analysis of pregnancy and gallbladder cancer. Results The adjusted odds ratios (OR) of the gestational age (3 times, 4 times, 5 times and 6 times) in each group with gallstone disease were 1.33 (95% CI: 0.59 2.99) , 1.34 (95% CI: 0.58 3.11), 1.39 (95% CI: 0.57 3.43) and 2.67 (95% CI: 1.12 6.41). Conclusions Multiple pregnancies may affect the occurrence of gallbladder cancer by cholelithiasis. Elevated levels of estrogen and progesterone in female may be responsible for the etiology of gallbladder carcinomas.