目的：用骨组织形态计量学探讨羟基脲对雄大鼠密质骨代谢的影响。方法：采用３月龄♂ＳＤ大鼠１６只，随机分为对照组和羟基脲组，前者喂生理盐水１ｍｌ／ｋｇ，后者每周喂羟基脲混悬液（１ｍｌ／ｋｇ）３次。处死大鼠前第１０天和第２天，分别给其皮下注射盐酸四环素（２５ｍｇ／ｋｇ），因其能螯合钙并主要沉积在新形成骨基质钙化的起始点，这样就在骨表面形成双层荧光，表明了分两次注射四环素期间骨形成的情况。３个月后取两组大鼠胫骨中段用甲基丙烯酸甲脂包埋不脱钙骨，再进行切片，经磨成２０μ的薄片用图象分析仪进行测算和分析。结果：羟基脲组和对照组比较：动态参数中内骨膜面皮质骨的骨吸收周长百分数增加１５６％（Ｐ＜０．０５），指示破骨细胞的活性明显增加，从而导致骨吸收增加；同时，机体为了阻止皮质骨的大量吸收，促使成骨细胞的数量、功能也增加，表现为内骨膜面皮质骨的荧光标记周长百分数增加８０％（Ｐ＜０．０５）、骨矿化沉积率增加３９７％（Ｐ＜０．０５）和骨形成率增加５２９％（Ｐ＜０．０５），出现骨形成加速和骨吸收增加这样一种皮质骨高转化率的局面。但是，从荧光周长与吸收周长之比来看，羟基脲组实际上减少了３６％，说明骨吸收大于骨形成且最终在静态参数中呈? OBJECTIVE: To investigate the effect of hydroxyurea on the metabolism of clumpy bone in male rats by using histomorphometry. Methods: Sixteen 3-month-old male SD rats were randomly divided into control group and hydroxyurea group. The former received normal saline (1 ml / kg) and the latter received hydroxyurea suspension (1 ml / kg) three times a week. On day 10 and day 2 before sacrifice, rats were subcutaneously injected with tetracycline hydrochloride (25 mg / kg), respectively, because they chelated calcium and mainly deposited at the starting point of newly formed bone matrix calcification, thus forming on the bone surface Double-layer fluorescence indicates the bone formation during tetracycline injections. Three months later, the middle of the tibia of the two groups of rats was taken and embedded with decalcified bone without methylmethacrylate. The slices were further sliced, and the images were polished and analyzed by an image analyzer. Results: Compared with the control group, the percentage of bone resorption periosteum in the dynamic parameters increased by 156% (P <0.05), which indicated that the activity of osteoclasts increased obviously, which led to the increase of bone resorption. At the same time, the body in order to prevent the massive absorption of cortical bone, prompting the number of osteoblasts, function also increased, the periosteal surface cortical bone fluorescent markers perimeter percentage increased by 80% (P <0.05), bone mineralization 397% (P <0.05), and bone formation rate increased 529% (P <0.05), and there was a case of high cortical bone turnover with increased bone formation and increased bone resorption. However, the ratio of fluorescence perimeter to absorption perimeter actually decreased by 36% in the hydroxyurea group, indicating that the bone resorption is greater than bone formation and ultimately appears as a static parameter