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目的:评价腹腔镜手术剥除卵巢畸胎瘤对机体免疫功能的影响。方法:选择卵巢畸胎瘤行开腹手术24例和腹腔镜手术43例,检测术前1d,术后1,4d外周血IL-6及T淋巴细胞亚群CD4/CD8水平。结果:腹腔镜组术前1d,术后1,4d外周血IL-6水平分别为62.09±9.29,91.67±8.73,66.84±9.77,开腹组分别为62.58±6.51,102.75±5.70,84.08±7.73,两组比较术前差异无统计学意义(P>0.05);术后1d,4d均差异有统计学意义(P<0.05);腹腔镜组术前1d,术后1,4d外周血CD4/CD8水平分别为1.88±0.56,1.77±0.67,1.85±0.53,开腹组分别为1.87±0.61,1.69±0.44,1.78±0.44,两组相比术前差异无统计学意义(P>0.05)术后1d,4d差异均有统计学意义(P<0.05);同时腹腔镜组术后4dIL-6,CD4/CD8水平与术前相比差异无统计学意义(P>0.05),而开腹组差异仍有统计学意义(P<0.05)。结论:腹腔镜下卵巢畸胎瘤剥除术损伤小,对机体体液免疫与细胞免疫功能影响均轻微,且恢复迅速。
Objective: To evaluate the effect of laparoscopic surgery on the removal of ovarian teratoma on immune function. Methods: Twenty-four cases of ovarian teratoma undergoing open surgery and 43 cases of laparoscopic surgery were enrolled in this study. The levels of CD4 / CD8 in peripheral blood IL-6 and T lymphocyte subsets were detected at 1 day before operation and at 1 day after operation. Results: The levels of IL-6 in the laparoscopic group were 62.09 ± 9.29,91.67 ± 8.73,66.84 ± 9.77 on the 1st day before operation and 62.58 ± 6.51,102.75 ± 5.70 and 84.08 ± 7.73 in the open group respectively , There was no significant difference between the two groups before surgery (P> 0.05), and the difference was statistically significant at 1 day and 4 days after operation (P <0.05) CD8 levels were 1.88 ± 0.56, 1.77 ± 0.67 and 1.85 ± 0.53, respectively, while those in open group were 1.87 ± 0.61, 1.69 ± 0.44 and 1.78 ± 0.44, respectively, there was no significant difference between the two groups (P> 0.05) There was no significant difference in the levels of IL-6 and CD4 / CD8 between the laparoscopic group and the preoperation group (P> 0.05) The difference was still statistically significant (P <0.05). Conclusions: Laparoscopic surgery for ovarian teratoma has the advantages of less damage and less influence on humoral immunity and cellular immunity, and rapid recovery.