随着肾移植技术的日趋成熟,现已成为治疗终末肾病最有效的方法。但排异导致的移植肾失功常常成为肾移植失败的最大障碍。移植前后HLA抗体的存在与移植肾排异和失功有关。然而,HLA抗体阴性的移植肾患者同样发生移植肾排异,提示可能有非HLA抗体在超急性、急性和移植肾失功发挥了 With the growing maturity of renal transplantation, has now become the most effective method of treatment of end-stage renal disease. However, renal failure caused by rejection often become the biggest obstacle to renal transplantation failure. The presence of HLA antibodies before and after transplantation was related to renal rejection and dysfunction. However, HLA-negative transplant recipients also had transplant rejection, suggesting that non-HLA antibodies may play a role in hyperacute, acute, and graft failure