Intensity-modulated proton therapy (IMPT) is becoming essential for proton therapy and is under rapid development. However, for IMPT, the lateral penumbra of the spot-scanning proton beam is still an urgent issue to be solved. Patient-specific block collimators (PSBCs), which can block unnecessary doses, play a crucial role in passive scattering delivery technology but are rarely used in spot scanning. One objective of this study is to investigate the lateral penumbra variations of intensity-modulated spot scanning with and without a PSBC. For fields with varying degrees of sharpness and at varying depths in a water phantom, the lateral penumbral widths were calculated using a Monte Carlo-based dose engine from RayStation 6. The results suggest that the lateral penumbral widths can be reduced by more than 30% for uniform target volumes, regardless of whether a range-shifter is used, and that the maximum dose beyond the field edges can be reduced significantly. The results of patient cases show that the doses in organs-at-risk near the edge of the target volume decrease if a PSBC is implemented. This study demon-strates that intensity-modulated spot scanning with a PSBC can effectively reduce the lateral penumbra and block unnecessary doses and is therefore promising for clinical applications in spot-scanning proton therapy.