论文部分内容阅读
目的对比老年帕金森伴精神障碍患者使用氟哌啶醇与利培酮治疗的疗效。方法 100例老年帕金森伴精神障碍患者,随机分为对照组与观察组,各50例。观察组患者给予氟哌啶醇治疗,对照组患者给予利培酮治疗。对治疗前后运动功能、精神抑郁、认知能力以及精神障碍程度进行评价,同时比较用药不良反应发生情况。结果治疗后,两组患者的阳性和阴性症状量表(PANSS)评分、简易精神状态量表(MMSE)评分、汉密尔顿抑郁量表(HAMD)评分、统一帕金森病评分分量表(UPDRS)评分均较治疗前改善,差异均具有统计学意义(P<0.05);组间治疗后比较,观察组PANSS评分及MMSE评分优于对照组,差异均具有统计学意义(P<0.05),两组HAMD评分及UPDRS评分比较,差异均无统计学意义(P>0.05)。观察组不良反应发生率为12.0%,对照组不良反应发生率为18.0%,比较差异无统计学意义(P>0.05)。结论运用氟哌啶醇治疗对老年帕金森伴精神障碍患者的精神障碍以及认知能力改善较利培酮有显著的优势。
Objective To compare the efficacy of haloperidol and risperidone in elderly patients with parkinsonism and mental disorders. Methods One hundred elderly Parkinson patients with mental disorders were randomly divided into control group and observation group, with 50 cases in each group. Patients in the observation group were treated with haloperidol, and patients in the control group were treated with risperidone. Before and after treatment, motor function, depression, cognitive ability and mental disorders were evaluated, and the incidence of adverse drug reactions were compared. Results After treatment, positive and negative symptom scores (PANSS), MMSE, HAMD, and UPDRS were significantly lower in both groups PANSS score and MMSE score of the observation group were better than those of the control group (P <0.05), and the differences were statistically significant (P <0.05). There was no significant difference between the two groups Score and UPDRS score, the difference was not statistically significant (P> 0.05). The incidence of adverse reactions in the observation group was 12.0%, while the incidence of adverse reactions in the control group was 18.0%, with no significant difference (P> 0.05). CONCLUSIONS: Haloperidol has a significant advantage over risperidone in improving mental disorders and cognitive abilities in elderly patients with parkinsonism.