采用微量微生物法定量测定脐门、外周静脉推注庆大霉素血药浓度,最高平均血药浓度分别为7.82±0.93μg/ml和10.21±1.22μg/ml,维持有效血药浓度时间分别为4.5～7.5小时和3.5～4.5小时。对外周静脉推注血药浓度进行药动学分析,该方式用药并不优于常规传统给药方式,而脐门静脉推注庆大霉素更符合治疗药效学要求,多数病例血药浓度所表现的“双峰”代谢特点值得进一步探讨。 Quantitative microbiological determination umbilical door, peripheral venous injection of gentamicin plasma concentration, the highest average plasma concentrations were 7.82 ± 0.93μg / ml and 10.21 ± 1.22μg / ml, the maintenance of effective plasma concentration time were 4.5 to 7.5 hours and 3.5 to 4.5 hours. Pharmacokinetic analysis of plasma concentration of peripheral venous bolus injection, the method is not superior to the traditional mode of administration, and umbilical portal vein injection of gentamycin more in line with the requirements of therapeutic pharmacodynamics, the majority of cases of plasma concentration The performance of the “bimodal” metabolic features worth further study.