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目的 探讨血浆、胃液环磷酸腺苷 (c AMP) ,环磷酸鸟苷 (c GMP) ,c AMP/ c GMP(CA/ CG)比值测定对鉴别良恶性胃病的临床意义。方法 对 1 0 7例因胃肠道症状接受胃镜检查配合活检确诊 ,分为慢性胃炎组 50例 ,溃疡病组 2 5例 ,胃癌组 32例 ,用放免法分别测定血浆、胃液 c AMP、 c GMP、 CA/ CG比值。结果 32例胃癌患者测定血浆 c GMP5.88± 1 .0 3pmol/ ml CA/ CG3.80～ 3.31及胃液 c GMP1 .0 3± 0 .1 7pmol/ ml,CA/ CG比值 2 .78～ 2 .2 9。与慢性胃炎组及溃疡病组相比 P值均 <0 .0 1 ,有显著性差异。血浆及胃液 c AMP分别及 1 8.70± 1 .38pmol/ ml及 2 .66±0 .57pmol/ ml与各组相比无差异 (P>0 .0 5)。结论 测定体液 c GMP及 CA/ CG辅助鉴别良恶性胃病有重要临床意义 ;对癌前状态高危人群定期检测环核苷酸可望提高早癌检出率 ;并可作为预估胃癌术后复发的一项指标
Objective To investigate the clinical significance of the ratio of cAMP, c GMP and cAMP / c GMP (CA / CG) in plasma and gastric juice to differentiate benign from malignant gastric diseases. Methods One hundred and seventy patients diagnosed by gastroscopy combined with biopsy were diagnosed as gastrointestinal symptoms. The patients were divided into chronic gastritis group (50 cases), ulcer disease group (25 cases) and gastric cancer group (32 cases). The levels of cAMP and c GMP, CA / CG ratio. Results The plasma levels of cGMP5.88 ± 1.30 pmol / ml CA / CG3.80 ~ 3.31 and gastric juice cGMP1 .0 3 ± 0.17 pmol / ml were measured in 32 patients with gastric cancer. The ratio of CA / CG was 2.78 ~ 2. 2 9. Compared with the chronic gastritis group and the ulcer group, the P values were <0.01, with significant difference. There was no difference in c AMP level between plasma and gastric juice (1.68 ± 1.38pmol / ml vs 2.66 ± 0.57pmol / ml) (P> 0.05). Conclusions The determination of cGMP and CA / CG in body fluids is of great clinical significance in the differential diagnosis of benign and malignant gastric diseases. The regular detection of cyclic nucleotides in precancerous populations is expected to improve the detection rate of early cancer, and may be used as a prognostic indicator of gastric cancer recurrence An indicator