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目的 观察缬沙坦的降压效果及其对高血压病患者左室功能的影响。方法 对 89例初诊轻、中度高血压病患者进行 4周的缬沙坦治疗 ,应用超声心动图观察左室收缩及舒张功能的变化。选择 3 6例不用药物治疗的高血压病患者作为对照。结果 缬沙坦治疗 4周后 ,用药组诊室收缩压和舒张压明显下降 (P <0 .0 5 ) ,而心房收缩期血流的峰值流速及流速积分明显加大 (P =0 .0 0 1及 <0 .0 5 ) ,E/A比值增加 (P <0 .0 1) ,对照组仍无明显变化。结论 缬沙坦在有效降压的同时能够明显改善高血压病患者的左室舒张功能。
Objective To observe the antihypertensive efficacy of valsartan and its effect on left ventricular function in patients with essential hypertension. Methods Eighty-nine patients with newly diagnosed mild to moderate essential hypertension were treated with valsartan for 4 weeks. The changes of left ventricular systolic and diastolic function were observed with echocardiography. Twenty-six hypertensive patients without medication were selected as controls. Results After 4 weeks of valsartan treatment, the systolic and diastolic blood pressure of the treatment group decreased significantly (P <0.05), but the peak flow velocity and the velocity integral of atrial systolic blood flow increased significantly (P = 0. 0 0 1 and <0. 05), E / A ratio increased (P <0.01), the control group still no significant change. Conclusion Valsartan can effectively improve left ventricular diastolic function in hypertensive patients while effectively lowering blood pressure.