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目的应用血管回声跟踪(ET)技术评价肥胖儿童颈总动脉弹性,探索儿童期肥胖对动脉弹性的影响。方法应用ET技术检测30例肥胖儿童双侧颈总动脉弹性参数:颈总动脉内中膜厚度(IMT)、压力应变弹性系数(Ep)、僵硬度(β)、顺应性(AC)和脉搏波传导速度(PWVβ),并与30例正常儿童对照组比较。结果肥胖组IMT、PWVβ、AC分别为(0.44±0.09)mm、(5.22±1.06)m/s、(1.79±0.28)mm2/k Pa,对照组IMT、PWVβ、AC分别为(0.42±0.10)mm、(6.88±1.04)m/s、(2.50±0.54)mm2/k Pa,2组比较差别无统计学意义(t=0.77、1.52、1.69,均P>0.05),肥胖组β、Ep分别为(3.99±1.89)、(56.84±17.94)k Pa,对照组β、Ep分别为(3.11±1.61)、(39.45±17.19)k Pa,肥胖组较对照组增高,差别有统计学意义(t=3.41、5.13,P<0.05或P<0.01)。结论肥胖儿童颈总动脉弹性在内中膜出现形态学改变前已有下降。
Objective To evaluate the elasticity of common carotid artery in obese children with vascular echo tracing (ET) and explore the effect of childhood obesity on arterial elasticity. Methods Bilateral common carotid artery parameters of 30 obese children were measured by ET technique: carotid artery IMT, Ep, stiffness, AC and pulse wave The conduction velocity (PWVβ) was compared with 30 normal children control group. Results The IMT, PWVβ and AC in obese group were (0.44 ± 0.09) mm and (5.22 ± 1.06) m / s and (1.79 ± 0.28) mm2 / kPa respectively, while those in control group were (0.42 ± 0.10) mm, (6.88 ± 1.04) m / s and (2.50 ± 0.54) mm2 / kPa, respectively. There was no significant difference between the two groups (t = 0.77,1.52 and 1.69, both P> 0.05) (3.99 ± 1.89) and (56.84 ± 17.94) kPa, respectively, and the values of β and Ep in the control group were (3.11 ± 1.61) and (39.45 ± 17.19) kPa, respectively, which were significantly higher in the obesity group than in the control group = 3.41,5.13, P <0.05 or P <0.01). Conclusion The common carotid artery elasticity of obese children has decreased before the morphological changes of the intima appear.