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本文综述了国内外关于失重对药物代谢动力学影响研究的现状及进展,重点阐述了失重引起的生理改变,包括体液头向转移、胃肠道功能紊乱和肝肾等器官血流的变化,如何影响药物在体内的吸收、分布、代谢和排泄等动力学过程,进而影响到其疗效的正常发挥,以便为国内载人飞行任务中航天员用药提供参考。
This review summarizes the current situation and progress of researches on the effects of weightlessness on pharmacokinetics at home and abroad, and focuses on the physiological changes caused by weightlessness, including head fluid transfer, gastrointestinal disorders and liver and kidney organ blood flow changes, etc. Affect the absorption, distribution, metabolism and excretion of drugs in the body and other kinetic processes, thus affecting the normal efficacy of its play in order to provide guidance for the domestic astronauts manned flights mission.