许多抗肿瘤药具有治疗指数低的特征,其药代动力学在病人个体间存在较大的差异,而且具有较高毒性。在临床上,对抗肿瘤药实行个体化给药已得到广泛的认同。本文对近年来国内外文献进行归纳分析,介绍剂量优化的几种方法,并对这些方法的原理、在药物治疗中的可行性及其在临床试验和实践中的应用进行了概述总结。 Many anti-tumor drugs have low therapeutic index characteristics, their pharmacokinetics in patients with large differences between individuals, but also with high toxicity. Clinically, the implementation of personalized anti-tumor drug delivery has been widely recognized. This article summarizes the domestic and foreign literatures in recent years, introduces several methods of dose optimization, and summarizes the principle of these methods, the feasibility of drug treatment and its application in clinical trials and practice.