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毒素性休克综合征(Toxic Shock Syndrome,TSS)首先由Todd(1978)描述、命名,是一种由金黄色葡萄球菌(以下简称金葡菌)引起的急性感染性疾患。主要症状是发高热、低血压、皮疹,多个器官受侵害,继而休克、死亡。Shrock(1980)发现青年妇女月经期间使用塞子(Tampon)与TSS有关,从而引起美国公众的注意;继之欧洲各国陆续有TSS病例报告。1982年曾有会议集与专著出版。近年来大量的实验研究与动物试验进一步阐明了病因与发病机理。现就TSS的临床表现、流行病学、病原学、发病机理与实验研究结果以及国内病例作一较全面述评。
Toxic Shock Syndrome (TSS) was first described and named by Todd (1978) as an acute infectious disease caused by Staphylococcus aureus (hereinafter referred to as Staphylococcus aureus). The main symptoms are high fever, hypotension, rash, multiple organ damage, followed by shock, death. Shrock (1980) found that the use of Tampons during menstruation in young women was associated with TSS, which attracted the attention of the American public; followed by successive cases of TSS in various European countries. In 1982, there were conferences and monographs published. In recent years, a large number of experimental studies and animal experiments further elucidate the etiology and pathogenesis. Now on the clinical manifestations of TSS, epidemiology, etiology, pathogenesis and experimental studies as well as domestic cases to make a more comprehensive review.