【摘 要】
：
目的:探讨人乳头瘤病毒(HPV)分型检测、脱氧核糖核酸(DNA)倍体分析联合p16/Ki-67双染在宫颈癌筛查中的应用价值.方法:选取2019年1月至2021年1月福建省妇幼保健院进行宫颈癌筛查的197例患者进行研究,观察并比较HPV分型检测、DNA倍体分析、p16/Ki-67双染三种检测方法单独及联合检测对宫颈阳性病变的诊断价值.结果:HPV分型检测、DNA倍体分析、p16/Ki-67双染三种检测方法单独检测结果均与病理活检结果的一致性计算结果分别为κ=0.658、0.622、0.570,P均<0.05
【机 构】
：
福建卫生职业技术学院,福建 闽侯 350101;福建省妇幼保健院,福建 福州 350001
论文部分内容阅读
目的:探讨人乳头瘤病毒(HPV)分型检测、脱氧核糖核酸(DNA)倍体分析联合p16/Ki-67双染在宫颈癌筛查中的应用价值.方法:选取2019年1月至2021年1月福建省妇幼保健院进行宫颈癌筛查的197例患者进行研究,观察并比较HPV分型检测、DNA倍体分析、p16/Ki-67双染三种检测方法单独及联合检测对宫颈阳性病变的诊断价值.结果:HPV分型检测、DNA倍体分析、p16/Ki-67双染三种检测方法单独检测结果均与病理活检结果的一致性计算结果分别为κ=0.658、0.622、0.570,P均<0.05;三者联合检测结果与病理活检结果具有较高一致性(κ=0.766,P<0.05);三者联合检测预测宫颈阳性病变的灵敏度和阴性预测值均高于HPV分型检测、DNA倍体分析和p16/Ki-67双染三种检测方法单独检测,准确度高于DNA倍体分析和p16/Ki-67双染2种单独检测,差异均有统计学意义(P<0.05).结论:HPV分型检测、DNA倍体分析以及p16/Ki-67双染无论是单独检测还是联合检测,都对宫颈阳性病变的诊断具有较高的检出率,而三者联合检测较单独检测更具优势,既能提高了宫颈癌的诊断效能,又能避免活检给患者带来的身体损伤.
其他文献
Objective:To investigate the value of routine intraoperative ultrasound(IU)and intraoperative contrast-enhanced ultrasound(ICEUS)in the surgical treatment of brain tumors,and to explore the utilization of ICEUS for the removal of the remnants surrounding
听神经瘤(acoustic neuroma,AN)是内听道及桥小脑角区最常见的良性肿瘤,占颅内肿瘤的 7％～12％、桥小脑角肿瘤的 80％～90％.每年听神经瘤发病率约 1/100000～5/100000.近 20 年来,随影像学诊断技术的发展,AN 检出率逐年增高,其诊断呈现出早期化、小型化的趋势.
目的:研究中医辨证分型结合胰岛素治疗小儿Ⅰ型糖尿病临床观察及对血糖水平的影响.方法:选取我院在2017年1月-2020年12月收治的40例小儿Ⅰ型糖尿病患者,将患者随机分为对照组与观察组,每组各20例,一个月为1个疗程,治疗时间为1年,观察两组患者的治疗总有效率、患者的血糖水平变化、患者预后的情况比较.结果:经过治疗后发现,观察组治疗的总有效率明显高于对照组,具有显著差异(P<0.05),观察组患者的血糖水平变化也优于对照组,P<0.05,差异具有统计学意义,患者预后的各种评分观察组患者也优于对照组患者,
Objective:The annual influenza epidemic is a heavy burden on the health care system,and has increasingly become a major public health problem in some areas,such as Hong Kong(China).Therefore,based on a variety of machine learning methods,and considering t
Objective:The systemic inflammatory response is regarded as the major cause of endotoxin-induced coagulopathy,which is a strong predictor of mortality in patients with severe sepsis.Simvastatin plays an important role in reducing inflammation.In addition,
Microvascular structure and hemodynamics are important indicators for the diagnosis and assessment of many diseases and pathologies.The structural and functional imaging of tissue microvasculature in vivo is a clinically significant objective for the deve
Objective:Cytogenetic abnormalities have been proven to be the most valuable parameter for risk stratification of childhood acute lymphoblastic leukemia(ALL).However,studies on the prevalence of cytogenetic abnormalities and their correlation to clinical
Objective:The present study was designed to evaluate the effects of adjuvant chemotherapy(CT)vs.radiotherapy(RT,alone or combined with CT)on the prognosis of patients with high-risk,early-stage(stage Ⅰ and stage Ⅱ)endometrioid endometrial carcinoma.Method
Objective:Conversion of normal cells to cancer cells is often accompanied by abnormal synthesis of serum enzymes.Both alkaline phosphatase(ALP)and lactate dehydrogenase(LDH)have been reported to have prognostic value in a variety of malignancies.The aim o
Objective:To investigate the feasibility and safety of achieving total enteroscopy by consecutive bidirectional double-balloon enteroscopy(DBE)procedures.Methods:The demographic data,indication,initial insertion route,examination time for each insertion a