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目的研究尖锐湿疣亚临床感染(SPI)转归与局部T淋巴细胞亚群变化的关系,进一步探讨SPI转归机制。方法对确诊的SPI患者进行:①所有患者随访8个月,每月观察1次,以临床表现和醋酸白试验判定SPI三种转归结局:发展为典型CA,SPI持续存在、SPI消失,依次分为A组、B组、C组;②免疫组织化学方法检测皮损组织和正常对照组织的T细胞亚群(CD_4~+,CD_8~+,CD_4~+/CD_8~+)的百分比,分析局部细胞免疫功能与三种转归结局的相关性。结果与正常组比较,SPI组CD_4~+细胞、CD_8~+细胞、CD_4~+/CD_8~+比值差异均有统计学意义(P<0.05)。SPI转归组中,A组与B组CD_4~+/CD_8~+比值差异无统计学意义(P>0.05),A组、B组分别与C组比较CD_4~+/CD_8~+比值差异均有统计学意义(P<0.05)。结论 SPI患者存在局部细胞免疫功能降低,局部细胞免疫功能强弱是决定SPI临床症状及转归的重要因素之一。
Objective To investigate the relationship between sub-clinical infection (SPI) of genital condyloma and changes of local T lymphocyte subsets, and to further explore the mechanism of SPI prognosis. Methods: All patients were followed up for 8 months and observed once a month. Three clinical outcomes and acetic acid white test were used to determine the outcome of three outcomes: development of typical CA, persistence of SPI, disappearance of SPI, Divided into group A, group B and group C. ② The percentage of T cell subsets (CD_4 ~ +, CD_8 ~ +, CD_4 ~ + / CD_8 ~ +) in skin lesions and normal controls were detected by immunohistochemistry Correlation between local cellular immune function and outcome of three outcomes. Results Compared with the normal group, the differences of the ratio of CD_4 ~ + cells, CD_8 ~ + cells and CD_4 ~ + / CD_8 ~ + in SPI group were statistically significant (P <0.05). There was no significant difference in the ratio of CD_4 ~ + / CD_8 ~ + between group A and group B (P> 0.05). The difference of CD_4 ~ + / CD_8 ~ + ratio between group A and group B There was statistical significance (P <0.05). Conclusion There is a reduction in local cellular immune function in SPI patients. Local cellular immune function is one of the important factors that determine the clinical symptoms and outcome of SPI.